Long-term treatment with standardized Ginkgo biloba Extract (EGb 761) attenuates cognitive deficits and hippocampal neuron loss in a gerbil model of vascular dementia
- Resource Type
- Authors
- Jocelyne Schulz; Sylvie Delaflotte; Denis Carré; Brigitte Spinnewyn; Michel Auguet; Marie-Noelle Rocher; Bernadette Pignol; P. E. Chabrier
- Source
- Fitoterapia. 82:1075-1080
- Subject
- Hippocampal formation
Pharmacology
Gerbil
Hippocampus
Neuroprotection
Brain Ischemia
law.invention
Memory
law
Drug Discovery
medicine
Animals
Dementia
Vascular dementia
Memory Disorders
biology
Plant Extracts
Superoxide Dismutase
Ginkgo biloba
business.industry
Dementia, Vascular
Cognition
General Medicine
medicine.disease
biology.organism_classification
Disease Models, Animal
Neuroprotective Agents
Anesthesia
Nerve Degeneration
Gerbillinae
business
Phytotherapy
- Language
- ISSN
- 0367-326X
The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral posttreatment with EGb 761 led to a significant recovery of spatial memory assessed by the object location test, inhibited the decrease in plasma SOD activity and protected the hippocampal CA1 neurons, even when administered after the insult. These data provide further evidence for the therapeutic potential of EGb 761 in the treatment of vascular dementia.