L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients
- Resource Type
- Authors
- Erica Bello; Jonathan Kerry; Bon Ham Yip; Sally Killick; Jacqueline Boultwood; Andrea Pellagatti; Shalini Singh; Rajko Kusec; Sophie Raynaud
- Source
- Haematologica. 103:e496-e500
- Subject
- 0301 basic medicine
Myelodysplastic syndromes
Chromosome
Translation (biology)
Hematology
Biology
medicine.disease
Molecular biology
LARP1
03 medical and health sciences
030104 developmental biology
Ribosomal protein
hemic and lymphatic diseases
medicine
Macrocytic anemia
Leucine
Haploinsufficiency
- Language
- ISSN
- 1592-8721
0390-6078
Deletion of the long arm of chromosome 5 [del(5q)] is the most common cytogenetic abnormality found in the myelodysplastic syndromes (MDS).[1][1] Patients with the 5q-syndrome have macrocytic anemia and the del(5q) as the sole karyotypic abnormality.[1][1] Haploinsufficiency of the ribosomal protein