Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice
- Resource Type
- Authors
- Bee Eng Ong; R. Dickinson; Jitka Aldhoun; Christopher J. Edge; Nicholas P. Franks; Serge C. Thal; Tobias Hirnet; Konstantin Radyushkin; Joanna Saville; Rita Campos-Pires; Flavia Valeo
- Source
- British journal of anaesthesia. 123(1)
- Subject
- Male
Xenon
hippocampus
nerve degeneration
Corpus callosum
BUPRENORPHINE
neuroinflammation
Mice
0302 clinical medicine
Cognition
030202 anesthesiology
Anesthesiology
Brain Injuries, Traumatic
Medicine
EPIDEMIOLOGY
Young adult
memory disorders
Neurons
traumatic brain injury
Sham surgery
Brain
3. Good health
D-ASPARTATE RECEPTOR
medicine.anatomical_structure
Neuroprotective Agents
Anesthesia
neuroprotection
medicine.symptom
Life Sciences & Biomedicine
Traumatic brain injury
HYPOPITUITARISM
Neuroprotection
White matter
03 medical and health sciences
ANALGESIA
INHALED XENON
Animals
general anaesthesia
Survival analysis
HYPOTHERMIA
Inflammation
Science & Technology
business.industry
1103 Clinical Sciences
Hypothermia
medicine.disease
COMPETITIVE-INHIBITION
Survival Analysis
Mice, Inbred C57BL
PATHOLOGY
Disease Models, Animal
Anesthesiology and Pain Medicine
Chronic Disease
business
Cognition Disorders
030217 neurology & neurosurgery
WHITE-MATTER DAMAGE
Follow-Up Studies
- Language
- ISSN
- 1471-6771
Background.Xenon is a noble gas with neuroprotective properties. We previously showed that xenon improves short and long-term outcomes in young adult mice after controlled cortical impact (CCI). This is a follow-up study investigating xenon’s effect on very long-term outcome and survival. Methods.C57BL/6N (n=72) young adult male mice received single CCI or sham surgery and were treated with either xenon (75%Xe:25%O2) or control gas (75% N2:25%O2). The outcomes used were: 1) 24-hour lesion volume and neurological outcome score; 2)contextual fear-conditioning at 2 weeks and 20 months; 3) corpus callosum white matter quantification; 4) immunohistological assessment of neuroinflammation and neuronal loss; 5) long-term survival. Results.Xenon treatment significantly reduced secondary injury development (p