Additional file 1: Supplementary Fig. S1. A: shCtr and SEMA6A-depleted A3 cells plated on poly-l lysine coated slides were treated or not with RhoA activator and stained with anti-YAP (red signal) or B: with Phalloidin (red signal). GFP reporter gene expression revealed successful silencing induction. The cells were counterstained with Hoechst to highlight nuclei. Scale bar 10 μm. Supplementary Fig. S2. Fold change number of viable shCtrl and SEMA6A-depleted A3 and H2 cells untreated and treated for 48 h with 0,1 μM dabrafenib (A) and 0,1 μM dabrafenib+ 5 nM trametinib (B) as compared with untreated shCtrl 2/59 cells. The results are presented as mean +/− standard deviation of three independent experiments.