Tesis doctoral.-- Universidad de Barcelona
Determining and understanding protein structure in atomic detail is a fundamental process to the advancement of biotechnology and biomedicine, shedding light the role of macromolecules and their complexes, their biological functions and pathways. The work presented in this thesis contributes to this aim by exploring new ways of identifying, analysing and classifying small, disconnected fragments and their association into local folds to provide specialised input models for X-ray crystallography phasing methods and as a general structural bioinformatics tool to enrich our insight of the results