The Relationship Between Long-term Use of Intranasal Corticosteroid and Intraocular Pressure
- Resource Type
- Authors
- Jemaima Che Hamzah; Ayesha Mohd Zain; Umi Kalthum Md Noh; Safinaz Mohd Khialdin; Norshamsiah Md Din; Salina Hussein
- Source
- Journal of Glaucoma. 28:321-324
- Subject
- Adult
Male
medicine.medical_specialty
Intraocular pressure
Adolescent
genetic structures
medicine.drug_class
Optic Disk
Glaucoma
Tonometry, Ocular
Young Adult
03 medical and health sciences
0302 clinical medicine
Ophthalmology
Anti-Allergic Agents
Optic Nerve Diseases
medicine
Humans
In patient
Young adult
Child
Glucocorticoids
Administration, Intranasal
Intraocular Pressure
medicine.diagnostic_test
business.industry
Beclomethasone
medicine.disease
Rhinitis, Allergic
eye diseases
Androstadienes
Cross-Sectional Studies
medicine.anatomical_structure
Eye examination
030221 ophthalmology & optometry
Corticosteroid
Female
Nasal administration
sense organs
business
Mometasone Furoate
030217 neurology & neurosurgery
Optic disc
- Language
- ISSN
- 1057-0829
Purpose The purpose of this study was to investigate the association between long-term intranasal steroid use and intraocular pressure (IOP) elevation. Patients and methods In total, 100 eyes from 50 patients on long-term intranasal steroids (>2 y) for allergic rhinitis and 90 eyes from 45 controls were included in this study. Patients on other forms of steroids and risk factors for glaucoma were excluded. IOP was measured and nonmydriatic stereoscopic optic disc photos were taken for each eye. The vertical cup-to-disc ratio and the status of the optic disc were evaluated. Results The mean IOP for intranasal steroids group was significantly higher (15.24±2.31 mm Hg) compared to the control group (13.91±1.86 mm Hg; P=0.000). However, there were no significant differences in the vertical cup-to-disc ratio and the status of glaucomatous optic disc changes between the groups. Conclusions Prolonged use of intranasal steroids cause statistical significant increase in IOP in patients with allergic rhinitis although no significant glaucomatous disc changes were seen. We suggest patients on long-term use of intranasal steroid have a yearly eye examination to be monitored for IOP elevation and those with additional risk factors for glaucoma is closely monitored for glaucoma.