Solitary CD8-Positive Primary Cutaneous Peripheral T-Cell Lymphoma: A Question of Classification
- Resource Type
- Authors
- Werner Kempf; Inês Rolim; Elizabeth West; Arti Bakshi; Richard Azurdia; Alistair Robson
- Source
- The American Journal of dermatopathology. 43(9)
- Subject
- Male
Pathology
medicine.medical_specialty
Skin Neoplasms
Dermatology
CD8-Positive T-Lymphocytes
Pathology and Forensic Medicine
Lesion
hemic and lymphatic diseases
medicine
Cytotoxic T cell
Humans
Aged, 80 and over
Scalp
integumentary system
business.industry
CD68
Not Otherwise Specified
General Medicine
medicine.disease
Immunohistochemistry
Lymphoma
Lymphoma, T-Cell, Cutaneous
medicine.anatomical_structure
Phenotype
Head and Neck Neoplasms
Forehead
medicine.symptom
business
CD8
- Language
- ISSN
- 1533-0311
Acral CD8(+) lymphoma is a provisional entity in the latest edition of the WHO Lymphoma Classification and is associated with a highly specific dot-like pattern of immunohistochemical expression of CD68. We report a case of an ulcerated solitary cutaneous lesion arising on the forehead of an adult man, which had a CD8(+) cytotoxic phenotype and areas of dot-like CD68 positivity, but with a number of features that significantly detracted from the classically described acral CD8(+) lymphoma. The nosological status of the lesion is discussed with respect to a preferred diagnosis of peripheral T-cell lymphoma, not otherwise specified.