Circulating CD4+ memory T cells give rise to a CD69+ resident memory T cell population in non-inflamed human skin
- Resource Type
- Authors
- Daniel J. Campbell; Maria M. Klicznik; Ariane Benedetti; Iris K. Gratz; Angelika Stoecklinger
- Source
- Subject
- 0303 health sciences
Adoptive cell transfer
education.field_of_study
Chemistry
T cell
Population
hemic and immune systems
chemical and pharmacologic phenomena
Inflammation
Human skin
Peripheral blood mononuclear cell
3. Good health
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Immunity
Immunology
medicine
medicine.symptom
education
Memory T cell
030304 developmental biology
030215 immunology
- Language
The blood of human adults contains a pool of circulating CD4+ memory T cells and normal human skin contains a CD4+CD69+ memory T cell population that produce IL17 in response to Candida albicans. Here we studied the generation of CD4+CD69+ memory T cells in human skin from a pool of circulating CD4+ memory T cells. Using adoptive transfer of human PBMC into a skin-humanized mouse model we discovered the generation of CD4+CD69+ resident memory T cells in human skin in absence of infection or inflammation. These CD4+CD69+ resident memory T cells were activated and displayed heightened effector function in response to Candida albicans. These studies demonstrate that a CD4+CD69+ T cell population can be established in human skin from a pool of circulating CD4+ memory T cells in absence of infection/inflammation. The described process might be a novel way to spread antigen-specific immunity at large barrier sites even in absence of infection or inflammation.