Tobacco use is associated with a worsening of symptoms of diabetes mellitus (DM), in particular, type 2 DM. Although medical advice encourages smoking cessation, studies show that 1 out of 5 people diagnosed with diabetes are not capable of reaching even maintaining abstinence by themselves. According to scientific evidence, the main barriers faced by diabetic patients during their smoking cessation attemps would be a higher rate of nicotine metabolism as well as an influence of genetics. Additionally, lower levels of insuline appear to increase the release of dopamine which may be responsible for alterations of the rewarding pathway of the brain. Therefore, people with diabetes would show a greater nicotine dependence than population without comorbidities. Assuming this information, it is possible to consider the urge of assessing suitable interventions for diabetic patients with nicotine dependence. With this purpose a systematic review of current evidence is proposed. The main goal is to identify and evaluate the efficacy of the different smoking cessation interventions aimed at adult population diagnosed with diabetes. Whereas secondary objective would be to stablish which smoking cessation techniques achieve greater effectiveness among diabetic population. Also, it is also intended to make a comparison between outcomes found in type 1 and type 2 DM in order to detect the best available intervention for both types of diabetes.