Integration of mechanics and biology in computer simulation of bone remodeling
- Resource Type
- Authors
- Anup Pant; Ali Vahdati; Glen L. Niebur; Elliot Paul
- Source
- Progress in Biophysics and Molecular Biology. 164:33-45
- Subject
- Process (engineering)
Osteoporosis
Biophysics
Research opportunities
Mechanics
medicine.disease
Models, Biological
Bone and Bones
Bone resorption
Bone remodeling
Mechanobiology
Osteogenesis
medicine
Computer Simulation
Bone formation
Bone Remodeling
Bone mechanics
Biology
Molecular Biology
- Language
- ISSN
- 0079-6107
Bone remodeling is a complex physiological process that spans across multiple spatial and temporal scales and is regulated by both mechanical and hormonal cues. An imbalance between bone resorption and bone formation in the process of bone remodeling may lead to various bone pathologies. One powerful and non-invasive approach to gain new insights into mechano-adaptive bone remodeling is computer modeling and simulation. Recent findings in bone physiology and advances in computer modeling have provided a unique opportunity to study the integration of mechanics and biology in bone remodeling. Our objective in this review is to critically appraise recent advances and developments and discuss future research opportunities in computational bone remodeling approaches that enable integration of mechanics and cellular and molecular pathways. Based on the critical appraisal of the relevant recent published literature, we conclude that multiscale in silico integration of personalized bone mechanics and mechanobiology combined with data science and analytics techniques offer the potential to deepen our knowledge of bone remodeling and provide ample opportunities for future research.