Severe financial crises could influence a country’s suicide trends and characteristics. We aimed to highlight differences among suicide completers before and after the onset of Greece’s serious debt crisis of 2010 based exclusively on forensic data. The sample’s size permitted a further elaboration by means of a time series analysis too. Data were collected from the Piraeus Department of Forensic Medicine for the period 1992–2016. We extracted information on sociodemographic parameters, psychiatric medication and alcohol intake, suicide method, place and month of suicide. The “after crisis onset” group (2011–2016) was significantly older (p = 0.039)—primarily due to differences in the 55–64 age group—, had more frequently used psychiatric medications (p