Carbamazepine-Induced Hematological and Immunological Alterations in Egyptian Children with Idiopathic Generalized Seizures
- Resource Type
- Authors
- Rana Atef Khashaba; Ola S El-Shimi; Amina Farag; Amany Mohammed El-Rebigi; Taghrid Gamaleldin Kharboush; Hanaa Bayomy
- Source
- Journal of Child Science. 11:e265-e272
- Subject
- medicine.medical_specialty
business.industry
Lymphocyte
Serum iga
Carbamazepine
Newly diagnosed
Gastroenterology
medicine.anatomical_structure
Internal medicine
Pediatrics, Perinatology and Child Health
Medicine
Surgery
business
medicine.drug
- Language
- ISSN
- 2474-5871
Carbamazepine (CBZ) is one of the oldest antiepileptic drugs (AEDs) that is still used for the treatment of tonic-clonic seizures in children. Long-term use of AEDs induces potential toxic effects that may remain undetermined for a long time. Earlier studies have revealed a wide spectrum of hematological toxicities associated with CBZ. This study was conducted to unveil the toxic effects of carbamazepine as an antiepileptic monotherapy on hematological and immunological parameters in a group of Egyptian pediatric patients using it for different durations. Fifty pediatric epileptics of either sex were enrolled; 38 were taking CBZ as antiepileptic monotherapy for ≥ 6 months and 12 were newly diagnosed untreated patients. Hematological and immunological parameters studied were compared with their age and sex-matched 15 controls and among groups. CBZ was found more toxic for total leukocyte count, lymphocyte count, serum IgA and IgM levels (p