Supplementary Data Figures 1 shows PK data on AD80. Supplementary Data Figure 2 shows PCA analysis. Supplementary Data Figure 3 shows Gene Set Enrichment of HUH7 cells in response to AD80 and sorafenib. Supplementary Data Figure 4 shows western blot data. Supplementary Data Figure 5 shows representative purification gels of p38 isoforms used in the study. Supplementary Data Figure 6 shows a p38 sequence alignment. Supplementary Data Figure 7 shows rescue data.