Impact of preconception weight loss on fasting glucose and pregnancy outcomes in women with obesity: A randomized trial
- Resource Type
- Authors
- Michael Permezel; Priya Sumithran; Alison Nankervis; Luke A. Prendergast; Joseph Proietto; Sarah A Price
- Source
- Obesity (Silver Spring, Md.)REFERENCES. 29(9)
- Subject
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
law.invention
Fasting glucose
Endocrinology
Randomized controlled trial
Weight loss
law
Pregnancy
Weight Loss
Medicine
Humans
Obesity
Nutrition and Dietetics
business.industry
Obstetrics
Infant, Newborn
Pregnancy Outcome
Fasting
medicine.disease
Glucose
Gestation
Female
medicine.symptom
business
Live birth
Body mass index
- Language
- ISSN
- 1930-739X
OBJECTIVE: This study examined the effectiveness of a nonsurgical, preconception weight loss intervention on pregnancy outcomes in women with obesity. METHODS: This was a two-arm, parallel-group randomized controlled trial. A total of 164 women with BMI 30 to 55 kg/m2 who were aged 18 to 38 years and planning pregnancy were randomized to a 12-week standard dietary intervention (SDI; n = 79) or a modified very low-energy diet (VLED; n = 85). Participants were observed for ≤48 weeks while trying for pregnancy and then during pregnancy. The primary outcome was maternal fasting plasma glucose at 26 to 28 weeks' gestation. Exploratory outcomes were individual and composite obesity-related adverse pregnancy outcomes. RESULTS: Weight loss was greater in the VLED group (SDI 3.2 [0.6] kg vs. VLED 13.0 [0.5] kg, p