Refractory Epilepsy as a Late Effect of Chemoradiation in Childhood Cancer: A Case Series
- Resource Type
- Authors
- Jeremy N. Wong; Alicia Lenzen; Rebecca García Sosa; John Stockman
- Source
- Pediatric Neurology. 127:56-59
- Subject
- Series (stratigraphy)
Pediatrics
medicine.medical_specialty
business.industry
Childhood cancer
Late effect
Cancer
medicine.disease
Pediatric cancer
Epilepsy
Developmental Neuroscience
Neurology
Quality of life
Pediatrics, Perinatology and Child Health
Refractory epilepsy
medicine
Neurology (clinical)
medicine.symptom
business
- Language
- ISSN
- 0887-8994
Refractory epilepsy can develop as a late complication for survivors of pediatric cancer with central nervous system involvement who undergo chemoradiation therapy. This case series reports three such patients who presented with atypical non-convulsive seizures up to 14 years after cancer diagnosis. We hypothesize that the development of refractory epilepsy may be a late effect of radiation treatment, as each patient underwent whole brain radiation. Given the high morbidity and mortality associated with epilepsy, early identification is crucial to improve outcomes and quality of life for this vulnerable population.