Fatal anaphylactoid reaction after primary exposure to aprotinin
- Resource Type
- Authors
- Pedro Lima; Luis Fernando López Almodóvar; Alfonso Cañas Cañas; Manuel Calleja
- Source
- Interactive CardioVascular and Thoracic Surgery. 5:25-26
- Subject
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Blood transfusion
business.industry
medicine.medical_treatment
Inflammatory response
Anaphylactic reaction
Mitral valve replacement
medicine.disease
Surgery
Cardiac surgery
Anesthesia
Medicine
Mitral valve replacement surgery
Aprotinin
Cardiology and Cardiovascular Medicine
business
hormones, hormone substitutes, and hormone antagonists
Anaphylaxis
medicine.drug
- Language
- ISSN
- 1569-9293
Aprotinin is widely used to prevent bleeding, inhibit systemic inflammatory response and reduce blood transfusions after cardiac surgery. Because it is a bovine protein, aprotinin can induce hypersensitivity reactions. We report a case of fatal anaphylactoid reaction to primary aprotinin exposure in a woman who was admitted for mitral valve replacement. The possibility of anaphylactic reaction should be considered whenever aprotinin is used.