ObjectivesLow central venous pressure (LCVP)‐assisted hepatectomy is associated with decreased blood loss and lower transfusion rates. Concerns about its impact on renal function have prevented widespread application. This study was conducted to review the dynamics of renal function after LCVP‐assisted hepatectomy.MethodsA retrospective analysis of a prospective surgical database was carried out. Estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation. The RIFLE (risk–injury–failure–loss–end‐stage) criteria were used to define postoperative biochemical acute kidney injury (bAKI). Occurrences of clinically relevant AKI (cAKI) were identified in the study center postoperative database.ResultsDuring the period 2003–2012, 2116 LCVP‐assisted hepatectomies were performed. The median patient age was 61 years [interquartile range (IQR): 51–70 years] and 51% of patients were male. The median number of resected segments was two; resections involved from one to four segments. Median estimated blood loss was 300 ml (IQR: 200–600 ml). Rates of morbidity and 90‐day mortality were 21% and 2%, respectively. Low baseline eGFR (