Elevated progesterone during ovarian stimulation for IVF
- Resource Type
- Authors
- Al-Azemi, M; Kyrou, D; Kolibianakis, E M; Humaidan, P; Van Vaerenbergh, I; Devroey, P; Fatemi, H M; Al Humaidan, Peter Samir Heskjær
- Source
- Al-Azemi, M, Kyrou, D, Kolibianakis, E M, Humaidan, P, Van Vaerenbergh, I, Devroey, P, Fatemi, H M & Al Humaidan, P S H 2012, ' Elevated progesterone during ovarian stimulation for IVF ', RBM Online, vol. 24, no. 4, pp. 381-8 . https://doi.org/10.1016/j.rbmo.2012.01.010
Al-Azemi, M, Kyrou, D, Kolibianakis, E M, Humaidan, P, Van Vaerenbergh, I, Devroey, P & Fatemi, H M 2012, ' Elevated progesterone during ovarian stimulation for IVF ', Reproductive BioMedicine Online, vol. 24, no. 4, pp. 381-8 . https://doi.org/10.1016/j.rbmo.2012.01.010
Vrije Universiteit Brussel
- Subject
- medicine.medical_specialty
endocrine system
Physiology
Stimulation
Fertilization in Vitro
Biology
progesterone
Elevated serum
Ovulation Induction
Obstetrics and gynaecology
Pregnancy
Internal medicine
Ongoing pregnancy
Adrenal Glands
Follicular phase
medicine
Animals
Humans
Progesterone
Ivf outcome
Elevated progesterone
business.industry
Ovary
Obstetrics and Gynecology
medicine.disease
female genital diseases and pregnancy complications
Up-Regulation
Endocrinology
Follicular Phase
Reproductive Medicine
Female
business
Developmental Biology
- Language
- English
There is an ongoing debate regarding the impact of premature progesterone rise on the IVF outcome. The objective of this review is to assess evidence of poorer ongoing pregnancy rate in IVF cycles with elevated serum progesterone at the end of follicular phase in ovarian stimulation. It also explores the origin of the progesterone rise, potential modifying factors and possible methods to prevent its rise during ovarian stimulation. This review draws on information already published from monitoring progesterone concentrations at the end of follicular phase in ovarian stimulation. The databases of Medline and PubMed were searched to identify relevant publications. Good-quality evidence supports the negative impact on endometrial receptivity of elevated progesterone concentrations at the end of the follicular phase in ovarian stimulation. Future trials should document the cause and origin of premature progesterone in stimulated IVF cycles. There is an ongoing debate regarding the impact of premature progesterone rise on the IVF outcome. The objective of this review is to assess evidence of poorer ongoing pregnancy rate in IVF cycles with elevated serum progesterone at the end of follicular phase in ovarian stimulation. It also explores the origin of the progesterone rise, potential modifying factors and possible methods to prevent its rise during ovarian stimulation. This review draws on information already published from monitoring progesterone concentrations at the end of follicular phase in ovarian stimulation. The databases of Medline and PubMed were searched to identify relevant publications. Good-quality evidence supports the negative impact on endometrial receptivity of elevated progesterone concentrations at the end of follicular phase in ovarian stimulation. Future trials should document the cause and origin of premature progesterone in stimulated IVF cycles.