Correlation between the −1562C/T polymorphism in the matrix metalloproteinase-9 gene and hemorrhagic transformation of ischemic stroke
- Resource Type
- Authors
- Xiaoman Zhang; Yuming Xu; Xinhui Cao; Aifan Li; Xiaoyu Xu
- Source
- Experimental and Therapeutic Medicine
- Subject
- Cancer Research
medicine.medical_specialty
Pathology
education.field_of_study
gene polymorphism
medicine.diagnostic_test
Oncogene
business.industry
Population
Magnetic resonance imaging
Articles
General Medicine
Gastroenterology
Molecular medicine
hemorrhagic transformation
Immunology and Microbiology (miscellaneous)
matrix metalloproteinase-9
Internal medicine
Genotype
medicine
Gene polymorphism
Allele
education
business
Allele frequency
- Language
- ISSN
- 1792-1015
1792-0981
The aim of the present study was to investigate the correlation between the −1562C/T polymorphism in an intron of the matrix metalloproteinase-9 (MMP-9) gene and hemorrhagic transformation of ischemic stroke (IS). Using polymerase chain reaction-restriction fragment length polymorphism, the −1562C/T polymorphisms in 222 patients with IS were detected. The patients were divided into hemorrhagic transformation (HT; 84 cases) and non-hemorrhagic transformation (NHT) groups (138 cases) depending on the results from the susceptibility-weighted magnetic resonance imaging, which was performed between one and two weeks following stroke onset. The allele frequencies were subsequently compared. Baseline data of the two groups were comparable. The HT group exhibited a significantly lower frequency of the CT+TT genotype compared with the NHT group (17.86 vs. 30.43%, P