The value of quantitative pentavalent 99mTc-dimercaptosuccinic acid scan in predicting progression-free survival and overall survival in patients with glioblastoma multiforme
- Resource Type
- Authors
- Ahmed Kandeel; Mahasen Abougabal; Ehab Saad; Ahmed A. Badawy
- Source
- Journal of Radiotherapy in Practice. 20:203-209
- Subject
- Oncology
medicine.medical_specialty
medicine.diagnostic_test
99mTc-Dimercaptosuccinic Acid
business.industry
medicine.medical_treatment
medicine.disease
Radiation therapy
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
medicine
Overall survival
Radiology, Nuclear Medicine and imaging
In patient
Progression-free survival
Prospective cohort study
business
030217 neurology & neurosurgery
Emission computed tomography
Glioblastoma
- Language
- ISSN
- 1467-1131
1460-3969
Aim:Glioblastoma multiforme (GBM) is the commonest and the most aggressive primary brain tumour. Pentavalent 99mTc-dimercaptosuccinic acid (99mTc (V)-DMSA) has been found to be a tumour-seeking agent. Pre-radiotherapy 99mTc (V)-DMSA positive scan was found to be significantly correlated with poor progression-free survival (PFS) and overall survival (OS). This study aims at evaluating the impact of quantitative 99mTc (V)-DMSA tumour uptake before and after radiotherapy on PFS and OS in patients with GBM.Methods:A prospective study included 40 patients with GBM. Single-photon emission computed tomography studies were done before and after adjuvant radiotherapy and were qualitatively and quantitatively evaluated. The retention index (RI) of the viable tumour was correlated with PFS and OS.Results:The qualitative enhancement of 99mTc (V)-DMSA uptake either positive or negative was significantly correlated with PFS at both early and late images (p-values 0·04 and 0·026, respectively) and OS only in the late image (p-value 0·036). The calculated ion/non-lesion ratios at late images were statistically correlated with PFS and OS (p-values 0·021 and 0·025, respectively). The baseline RI had significant correlation with PFS only (p-value 0·01).Conclusion:The degree of 99mTc (V)-DMSA scan positivity is a poor prognostic factor for PFS and OS in GBM patients.