DNA Synthesis in Periportal and Perivenous Hepatocytes of Intact and Hepatectomized Young Mice
- Resource Type
- Authors
- Ana María Inda; Ana Lía Errecalde; A. Fernández-Blanco
- Source
- Journal of Immunoassay and Immunochemistry. 36:456-463
- Subject
- DNA Replication
Male
Mice, Inbred C3H
medicine.medical_specialty
DNA synthesis
Clinical Biochemistry
Immunology
Biology
Liver regeneration
Mice
Medical Laboratory Technology
chemistry.chemical_compound
Endocrinology
chemistry
Internal medicine
Surgical removal
Hepatocytes
medicine
Animals
Hepatectomy
Immunology and Allergy
Circadian rhythm
Bromodeoxyuridine
- Language
- ISSN
- 1532-4230
1532-1819
DNA synthesis of hepatocytes in two areas of Intact and Hepatectomized young mice liver along a circadian period was studied. DNA synthesis was significantly different at all analyzed time points in Intact and Hepatectomized animals. Differences between periportal and perivenous hepatocytes were found in hepatectomized animals at 04/42 and 08/46 hr of day/hour post-hepatectomy. DNAs peak in periportal hepatocytes regenerating liver occurs 4 hr earlier than in perivenous hepatocytes, probably reflecting their shorter G1 phase. Besides, daily mean values of regenerating livers were higher than those observed in Intact animals, as a consequence of surgical removal.