Supplemental Material for A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III) by Wendy C Ziai, Nichol McBee, Karen Lane, Kennedy R Lees, Jesse Dawson, Paul Vespa, Richard E Thompson, A David Mendelow, Carlos S Kase, J Ricardo Carhuapoma, Carol B Thompson, Steven W Mayo, Pat Reilly, Scott Janis, Craig S Anderson, Mark R Harrigan, Paul J Camarata, Jean-Louis Caron, Mario Zuccarello, Issam A Awad, Daniel F Hanley and On Behalf of the MISTIE III Investigators in International Journal of Stroke