Brain tumors are the second most common cause of seizures identified in large epilepsy surgical series. Within the broad spectrum of brain tumors, specific types are more frequently associated with seizures which are called long-term epilepsy- associated tumors (LEATs). Most common LEATs are glioneuronal tumors, dysembryoplastic neuroepithelial tumors (DNET), and gangliogliomas (GG), but also papillary glioneuronal tumors, angiocentric glioma, isomorphic diffuse glioma, multinodular and vacuolating neuronal tumors of the cerebrum and polymorphous low-grade neuroepithelial tumor. LEATs are regularly treated by surgical resection with seizure-free rates ranging from 77% to 93% for DNETs and 63% to 100% for GGs. Although LEATs are predominantly benign tumors, sometimes seizures are refractory to antiepileptic treatments, resulting in drug- resistant tumor-related epilepsy, long-term disability, and patient morbidity with a profound impact on quality of life. Common features of LEATs are seizure onset at a young age (