Three new dimeric sesquiterpenoids, chloramultilides B−D ( 1− 3), along with 10 known sesquiterpenoids, were isolated from the whole plant of Chloranthus spicatus. Their structures were established by physical data (1D and 2D NMR, MS). The structure and absolute configuration of 1was confirmed by X-ray crystallography. Compound 1exhibited moderate in vitroantifungal activity.