In progressive familial intrahepatic cholestasis type 2 (PFIC‐2), severe steatorrhea is often documented. However, pancreatic exocrine secretion has not yet been studied. In 14 children with PFIC‐2, pancreatic function was assessed using standard fecal tests. Normal fecal lipase concentrations excluded isolated lipase deficiency. No differences in fecal elastase‐1 concentrations and chymotrypsin activities were detected between PFIC‐2 patients with or without steatorrhea, nor between these patients and healthysubjects. In conclusion, pancreatic exocrine function in patients with PFIC‐2 is normal. Steatorrhea observed in those patients isnot related to pancreatic insufficiency.