Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives
- Resource Type
- Article
- Authors
- Huang, Ruoyan; Chen, Xingkuan; Mou, Chengli; Luo, Guoyong; Li, Yongjia; Li, Xiangyang; Xue, Wei; Jin, Zhichao; Chi, Yonggui Robin
- Source
- Organic Letters; June 2019, Vol. 21 Issue: 11 p4340-4344, 5p
- Subject
- Language
- ISSN
- 15237060; 15237052
An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.