Can Tho City is located in the middle of the Mekong Delta, where the effects of climate change have been and will continue to be considerable. According to climate change predictions, the city is one of five regions that could be affected. In this study, we conducted analysis of trends of Tmaxand Tminover 39 years using monthly temperature in Can Tho City. We employed a Box plot, Mann–Kendall test, and Sequential Trend Analysis (SMK). Tmaxand Tminincreased for all 12 months from 1984 to 2022, with Sen’s slopes of 0.45°C/decade and 0.29°C/decade, respectively. Although Tminshows a slower rate of increase than Tmax, the increase in Tminindicates that the temperature in Can Tho has risen.