The logistics and location decisions for a closed-loop logistic system with multiple suppliers, manufactories, distribution centers and customers is considered. Particularly, the demands of customers are uncertainty, and can be described as a scenario set with certain probability. By using the robust optimization method based on scenario analyses approach, a robust logistics and location decisions model is constructed to minimize the total cost of the transportation and the operations by optimally selecting the places of manufactories, distribution centers with the respective operation units. A numerical example is designed to verify the robustness of the proposed model.