Pregnenolone and Dehydroepiandrosterone as an Adjunctive Treatment in Schizophrenia and Schizoaffective Disorder: An 8-Week, Double-Blind, Randomized, Controlled, 2-Center, Parallel-Group Trial.
- Resource Type
- Article
- Authors
- Ritsner, Michael S.; Gibel, Anatoly; Shleifer, Tatyana; Boguslavsky, Igor; Zayed, Ahmad; Maayan, Rachel; Weizman, Abraham; Lerner, Vladimir
- Source
- Journal of Clinical Psychiatry; Oct2010, Vol. 71 Issue 10, p1351-1362, 12p, 1 Diagram, 3 Charts, 3 Graphs
- Subject
- PREGNENOLONE
DEHYDROEPIANDROSTERONE
SCHIZOPHRENIA treatment
SCHIZOAFFECTIVE disorders
DRUG efficacy
THERAPEUTICS
- Language
- ISSN
- 01606689
The article presents a study which examines the effectiveness of pregnenolone (PREG) and dehydroepiandrosterone (DHEA) as an adjunctive treatment for schizophrenia and schizoaffective disorder. In the study, researchers analyzed the conditions of 58 chronic schizophrenia or schizoaffective disorder patients. They found that patients who received PREG-30 showed reduced positive symptoms scores and extrapyramidal side effects (EPS) and enhanced attention and working memory.