This study analyzed the characteristics of BRAFV600Emutation in papillary thyroid carcinoma (PTC) in Chinese coastal areas. We intended to identify noninvasive methods to determine BRAFV600Estatus in thyroid nodules prior to surgery. BRAFV600Emutation and the sonographic characteristics of thyroid nodules were investigated in 670 PTC patients in our hospital. We aimed to determine the relationship between BRAFV600Emutation and the clinicopathological and sonographic imaging characteristics of PTC. The mutation rate of the BRAFV600Ewas 78.2%. BRAFV600Emutation was significantly associated with central node (univariate analyses, P= .005; multivariate analyses, P< .001, odds ratio [OR] = 10.255) and lateral node metastases (univariate analyses, P= .001; multivariate analyses, P< .001, OR = 22). It was less frequent in PTC coexisting with Hashimoto’s thyroiditis (univariate analyses, P= .016; multivariate analyses, P< .001, OR = .034). Nodules without blood flow had a significantly higher mutation rate of BRAFV600Ein PTC patients (univariate analyses, P= .026). BRAFV600Emutation was significantly associated with high suspicion in the Thyroid Imaging Reporting and Data System 5 (univariate analyses, P= .004; multivariate analyses, P= .014, OR = 6.456). Our results strongly suggest that BRAFV600Emutation plays a potential role in lymph node metastasis (central node metastasis, OR = 10.225; lateral node metastasis, OR = 22). Some sonographic imaging features might be helpful in estimating the status of BRAFV600Epreoperatively.