Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
- Resource Type
- Article
- Authors
- Willis, Nicky J.; Mahy, William; Sipthorp, James; Zhao, Yuguang; Woodward, Hannah L.; Atkinson, Benjamin N.; Bayle, Elliott D.; Svensson, Fredrik; Frew, Sarah; Jeganathan, Fiona; Monaghan, Amy; Benvegnù, Stefano; Jolly, Sarah; Vecchia, Luca; Ruza, Reinis R.; Kjær, Svend; Howell, Steven; Snijders, Ambrosius P.; Bictash, Magda; Salinas, Patricia C.
- Source
- Journal of Medicinal Chemistry; 5/26/2022, Vol. 65 Issue 10, p7212-7230, 19p
- Subject
- Language
- ISSN
- 00222623