Guizhou province has rich bio-resource and needs a mass of talents to develop it. Therefore, bio-resource-major in Guizhou province should be to train bio-resource-development talents as teaching goal. But existing bio-resource course system in our college can not be able to fulfil the teaching goal, for which the course system need to reform. To adapt to requirement of the course system reformation, new course system of bio-resource-major was discussed and established. The basis on which new course system was set up was knowledge and technique system needed in overall process of bio-resource development.