Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.
- Resource Type
- Article
- Authors
- Skopek, T R; Liber, H L; Kaden, D A; Thilly, W G
- Source
- Proceedings of the National Academy of Sciences of the United States of America; September 1978, Vol. 75 Issue: 9 p4465-4469, 5p
- Subject
- Language
- ISSN
- 00278424; 10916490
Forward mutation to 8-azaguanine resistance and reverse mutation to histidine prototrophy were measured in Salmonella typhimurium after treatment with 16 mutagens of both base-substitution and frameshift classes. The two approaches were found to be equisensitive for all 16 mutagens--i.e., induction of significant mutation occurred at similar concentrations in the forward mutation assay and in the most sensitive of the five Ames tester strains.