Early Initiation of Ketamine Infusion for Pain Management in Pediatric BMT Patients with Mucositis
- Resource Type
- Article
- Authors
- Utley, Kaylyn; Azadegan, Ali; Rosenbaum, Adam Rene; McGinn, Brenna; Deis, Amanda; Hamer, Katie; Barthelmess, Erin; David, Alexandria; Southworth, Debra; Trawick, Cyndi; Tan, Gee Mei; Fabrizio, Vanessa A.
- Source
- Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p3545-3545, 1p
- Subject
- Language
- ISSN
- 00064971; 15280020
Background: As many as 90% of children undergoing hematopoietic stem cell transplant (HSCT) will experience painful mucositis. The mainstay of treatment for these children has been opioid analgesia which can be associated with sedation and respiratory depression. Additionally, these children may experience heightened opioid tolerance and physiologic dependence contributing to lengthy admissions. Ketamine is an anesthetic and analgesic which has been used successfully in conjunction with opioids in the treatment of painful mucositis. This study aimed to reduce total opioid use per day by 10% and overall pain scores by 2 in pediatric patients with mucositis undergoing HSCT through initiation of ketamine at the same time as an opioid patient-controlled analgesia (PCA).