The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention.
- Resource Type
- Article
- Authors
- Kopelovicg, Levy; Fay, Judith R.; Sigman, Caroline C.; Crowell, James A.
- Source
- Cancer Epidemiology, Biomarkers & Prevention; Jul2007, Vol. 16 Issue 7, p1330-1340, 11p, 2 Diagrams, 2 Charts
- Subject
- Language
- ISSN
- 10559965
The article presents a study which focused on the mammalian target of rapamycin (mTOR) as a possible target for cancer chemoprevention. mTOR is a key signaling node coordinating cell cycle progression and cell growth, where its signaling pathways are dysregulated in precancerous human tissues. Suppression of mTOR signaling holds potential antitumor actions of caloric restriction.