Persistent Expansion, in a Human Immunodeficiency Virus-Infected Person, of V{beta}-Restricted CD4+CD8+ T Lymphocytes that Express Cytotoxicity-Associated Molecules and Are Committed to Produce Interferon-{gamma} and Tumor Necrosis Factor-{alpha}
- Resource Type
- Article
- Authors
- Weiss, Laurence; Roux, Anne; Garcia, Sylvie; Demouchy, Catherine; Haeffner-Cavaillon, Nicole; Kazatchkine, Michel D.; Gougeon, Marie-Lise
- Source
- The Journal of Infectious Diseases; October 1998, Vol. 178 Issue: 4 p1158-1158, 1p
- Subject
- Language
- ISSN
- 00221899; 15376613
The present study describes the persistent expansion of a subpopulation of circulating double-positive CD4+CD8+ T cells in a human immunodeficiency virus (HIV)—infected person over 8 years. The percentage of double-positive cells was remarkably stable with time and was not related to HIV plasma virus load. CD4+CD8+ cells exhibited phenotypic characteristics of activated memory T lymphocytes. Analysis of Vβ usage by the T cell receptors of these cells indicated restricted expression to the Vβ14 and Vβ17 families. Most CD4+CD8+ cells constitutively expressed cytotoxicity-associated molecules (C1.7 and perforin) and were selectively committed to produce interferon-γ and tumor necrosis factor-α, cytokines involved in cytotoxic function. The kinetics of changes in the relative proportion of single-positive CD4+ and double-positive CD4+CD8+ T cell subsets and a similar bias in Vβ usage by these subsets suggest that CD4+CD8+ lymphocytes originate from peripheral expansion of mature CD4+ T cells.