Rhodium-catalyzed formal [4 + 3] annulation reaction of N-methoxybenzamides with gem‑difluorocyclopropenes: A combination of experimental and theoretical studies
- Resource Type
- Article
- Authors
- He, Yimiao; Tian, Limei; Chang, Xuexue; Qu, Zeming; Huang, Yanmin; Huang, Chusheng; Sun, Qing; Wang, Honggen
- Source
- Chinese Chemical Letters; June 2022, Vol. 33 Issue: 6 p2987-2992, 6p
- Subject
- Language
- ISSN
- 10018417
A rhodium-catalyzed [4 + 3] cycloaddition reaction between N-methoxybenzamides and gem‑difluorocyclopropenes is described. The reaction offers a mild and efficient approach towards the synthesis of fluorinated 2H-azepin-2-ones with broad substrate scope. A consecutive HOAc-assisted CN bond formation and fluorine elimination are involved as key steps for success as illustrated by detailed DFT studies.