Activity of compound G2 isolated from alfalfa roots against medically important yeasts
- Resource Type
- Article
- Authors
- Polacheck, I; Zehavi, U; Naim, M; Levy, M; Evron, R
- Source
- Antimicrobial Agents and Chemotherapy; August 1986, Vol. 30 Issue: 2 p290-294, 5p
- Subject
- Language
- ISSN
- 00664804; 10986596
An antimycotic agent was isolated from roots of alfalfa and further purified to yield a nonhemolytic, homogeneous compound (G2). This compound contained considerable activity against 10 medically important yeasts. MICs obtained by both agar and broth dilution methods ranged from 3 to 15 micrograms/ml. Compound G2 was fungicidal at a relatively low concentration for nine different species of yeasts tested (minimum fungicidal concentrations ranged between 6 and 24 micrograms/ml). The considerable stability of compound G2 and its strong inhibitory and fungicidal activity against a broad range of yeasts suggest that after further development it might be useful as an active agent in the treatment of mycotic infections.