Understanding Intent to treat analyses: An important Lesson from the International Cooperative Study on the Timing of Aneurysm Surgery
- Resource Type
- Article
- Authors
- Olijnyk, Leonardo; Darsaut, Tim E.; Öhman, Juha; Raymond, Jean
- Source
- Neurochirurgie; 20220101, Issue: Preprints
- Subject
- Language
- ISSN
- 00283770
Background and purpose: Intention-to-treat analyses (ITT) are the best way to analyze randomized clinical trials because they preserve the benefits of randomization: to provide an unbiased assessment of relative treatment effects. Yet they play a more fundamental role, which can be demonstrated in observational studies.