No Evidence of Plasmodium falciparumk13Artemisinin Resistance-Conferring Mutations over a 24-Year Analysis in Coastal Kenya but a Near Complete Reversion to Chloroquine-Sensitive Parasites
- Resource Type
- Article
- Authors
- Wamae, Kevin; Okanda, Dorcas; Ndwiga, Leonard; Osoti, Victor; Kimenyi, Kelvin M.; Abdi, Abdirahman I.; Bejon, Philip; Sutherland, Colin; Ochola-Oyier, Lynette Isabella
- Source
- Antimicrobial Agents and Chemotherapy; September 2019, Vol. 63 Issue: 12
- Subject
- Language
- ISSN
- 00664804; 10986596
Antimalarial drug resistance is a substantial impediment to malaria control. The spread of resistance has been described using genetic markers, which are important epidemiological tools. We carried out a temporal analysis of changes in allele frequencies of 12 drug resistance markers over 2 decades of changing antimalarial drug policy in Kenya.