Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence
- Resource Type
- Article
- Authors
- Volonte, Daniela; Liu, Zhongmin; Musille, Paul M.; Stoppani, Elena; Wakabayashi, Nobunao; Di, Yuan-Pu; Lisanti, Michael P.; Kensler, Thomas W.; Galbiati, Ferruccio
- Source
- Molecular Biology of the Cell; June 2013, Vol. 24 Issue: 12 p1852-1862, 11p
- Subject
- Language
- ISSN
- 10591524; 19394586
Reactive oxygen species can induce premature senescence. Caveolin-1 promotes oxidative stress–induced activation of the p53/p21Waf1/Cip1 pathway and development of premature senescence by acting as an endogenous inhibitor of the transcription factor Nrf2.