Two Cases With Features of Lymphocyte Variant Hypereosinophilic Syndrome With STAT3SH2 Domain Mutations
- Resource Type
- Article
- Authors
- Fernandez-Pol, Sebastian; Petersen, Bruce; Murphy, Jo-Ellen; Oak, Jean S.; Wang, Erica B.K.; Rieger, Kerri E.; Kim, Youn H.; Khodadoust, Michael S.; Suarez, Carlos J.
- Source
- The American Journal of Surgical Pathology; February 2021, Vol. 45 Issue: 2 p193-199, 7p
- Subject
- Language
- ISSN
- 01475185; 15320979
Lymphocyte variant hypereosinophilic syndrome (LV-HES) is a rare cause of eosinophilia that is due to eosinophilipoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is largely unknown and only 1 case of LV-HES with a pathogenic STAT3mutation has been described thus far. Here we report 2 cases of LV-HES with STAT3SH2 domain mutations. These cases further support the model that activation of STAT3 signaling through STAT3SH2 domain mutations is a recurrent event in LV-HES.