B Cell Receptors Of Chlamydophila Psittacinegative MALT Lymphomas Of The Ocular Adnexa Recognize Common Self-Antigens
- Resource Type
- Article
- Authors
- Zhu, Daxing; Lu, Xiaoqing; Minden, Marcus Dühren-von; Bhatt, Shruti; Lossos, Chen; Chapman-Fredricks, Jennifer R.; Veelken, Hendrik; Jumaa, Hassan; Lossos, Izidore S
- Source
- Blood; November 2013, Vol. 122 Issue: 21 p4266-4266, 1p
- Subject
- Language
- ISSN
- 00064971; 15280020
Ocular adnexal mucosa associated lymphoid tissue lymphomas (OAMALTLs) are the most common lymphomas in the ocular adnexa. The etiology and pathogenesis of OAMALTLs are still controversial. Association with Chlamydophila (C.) psittaciinfection demonstrates marked geographic differences. We have previously reported biased IGHV(IGHV4family and IGHV4-34gene) and IGKV(IGKV3-20) usage in C. psittaci-negative OAMALTLs (PLoS One. 2011;6(12):e29114; Am J Hematol.2013; 88:379). However, the identity and role of potential antigens (Ags) in OAMALTL pathogenesis are unknown. Herein we evaluated the reactivity of OAMALTLs derived B-cell receptors (BCRs) for bacterial and human antigens.