The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart
- Resource Type
- Article
- Authors
- Pavlović, M.; Petković, D.; Cvetković, M.; Macut, D. J.; Zdjelar, K.; Nešić, M.; Bosnić, O.; Radulović, R.; Mihajlović, M.
- Source
- Experientia; September 1995, Vol. 51 p941-944, 4p
- Subject
- Language
- ISSN
- 00144754
The mechanism of the positive inotropic effect of prostacyclin (PGI2) (2.6×10−6mol/l) on the isolated right ventricle of rat heart was studied. Our results show that the positive inotropic effect of prostacyclin is produced indirectly through beta adrenoceptors and slow Ca2+channels, because blockade of slow Ca2+channels with verapamil (10−6mol/l) and beta adrenoceptors with propranolol (10−6mol/l) abolishes this effect. Alpha adrenoceptors do not mediate the action of PGI2.