A redox-responsive mesoporous silica based nanoplatform for in vitrotumor-specific fluorescence imaging and enhanced photodynamic therapyElectronic supplementary information (ESI) available: Synthesis of BHQ-MSN-SS-PpIX&RGD and the peptide analogs; ESI of multifunctional peptides; UV-Vis spectrum of BHQ-MSN-NH2; FTIR spectra of BHQ-MSN-SS-alkyne and BHQ-MSN-SS-PpIX&RGD. See DOI: 10.1039/c7bm00793k
- Resource Type
- Article
- Authors
- Yuan, Fan; Li, Jiang-Lan; Cheng, Han; Zeng, Xuan; Zhang, Xian-Zheng
- Source
- Biomaterials Science; 2017, Vol. 6 Issue: 1 p96-100, 5p
- Subject
- Language
- ISSN
- 20474830; 20474849
In order to obtain an optimal therapeutic effect with minimal systemic toxicity, a redox-responsive mesoporous silica nanoparticle (MSN)-based platform modified with protoporphyrin IX (PpIX)-multifunctional peptides was synthesized as an intelligent theranostic agent carrier. This redox-responsive nanoplatform could release the theranostic agent under a glutathione stimulus, produce fluorescence recovery for tumor-specific fluorescence imaging and provide tumor-enhanced photodynamic therapy.