Down-regulation of the Wnt/β-catenin signaling pathway by Cacnb4
- Resource Type
- Article
- Authors
- Rima, Mohamad; Daghsni, Marwa; Lopez, Anaïs; Fajloun, Ziad; Lefrancois, Lydie; Dunach, Mireia; Mori, Yasuo; Merle, Philippe; Brusés, Juan L.; De Waard, Michel; Ronjat, Michel
- Source
- Molecular Biology of the Cell; 2017, Vol. 28 Issue: 25 p3699-3708, 10p
- Subject
- Language
- ISSN
- 10591524; 19394586
The cytoplasmic β4-subunit of the voltage-gated calcium channels has been shown be involved in the regulation of gene transcription. This subunit interacts with the transcription factor TCF4 and inhibits the Wnt/β-catenin signaling pathway. These results may also explain the inhibitory effect of the β4-subunit on cell proliferation.