Sorazolons, Carbazole Alkaloids from Sorangium cellulosumStrain Soce375
- Resource Type
- Article
- Authors
- Karwehl, Sabrina; Jansen, Rolf; Huch, Volker; Stadler, Marc
- Source
- Journal of Natural Products; February 2016, Vol. 79 Issue: 2 p369-375, 7p
- Subject
- Language
- ISSN
- 01633864; 15206025
Sorazolons A (1) to E2 (9) were isolated from Sorangium cellulosumstrain Soce375. Their molecular structures were elucidated using extensive HRESIMS and NMR analysis. The absolute configuration of sorazolon A (1) was determined by comparison of the experimental CD spectrum with quantum chemical calculated spectra for both enantiomers. Sorazolons D2 (7), E (8), and E2 (9) exhibit a moderate cytotoxic activity against mouse fibroblast cell line L929 with IC50values between 5.0 μM and 0.09 mM.