While ventilation with the guidance of plateau airway pressure is essential part of lung protective ventilation other physiologic monitoring tools like driving pressure (DP), transpulmonary pressure (PL) and mechanical power (MP) are also investigating for this aim. The majority of data regarding these parameters come from patients with ARDS. However, VILI is not just a problem in patients with ARDS but in all critically ill patients receiving mechanical ventilation. The aim of the study was to investigate the safety thresholds' of physiologic parameters consistency each other for safe mechanical ventilation (MV) in ICU patients.