Drought vulnerability assessment plays an important role in mitigation and response to drought, which can help the decision makers conduct effective management strategies associated with disaster reduction. Based on the meteorological data related to precipitation and temperature from 1980 to 2015, this paper proposes a detailed framework for drought vulnerability analysis of the Qinghai-Tibet Plateau, where the temporal and spatial distributions of meteorological drought index and drought vulnerability based on IDW interpolation method can be generated. Results indicate that the Qinghai-Tibet Plateau shows a drought trend, and a slightly dry state has happened since 2005. Additionally, a slight spatial variation in drought vulnerability across the region could be found, in which the eastern and western of this region have relatively lower vulnerabilities, while the central part shows a relatively higher vulnerability. Generally, there is a drought trend in this region but without a deterioration tendency.