LAG3 disrupts the TCR signal by local acidification
- Resource Type
- Article
- Authors
- Hivroz, Claire
- Source
- Nature Immunology; 20220101, Issue: Preprints p1-2, 2p
- Subject
- Language
- ISSN
- 15292908; 15292916
LAG3 interferes with TCR signaling by lowering the pH in the vicinity of the TCR and inducing dissociation of the key signaling kinase Lck from the co-receptors CD8 and CD4.